The analgesic, haematological and some physiological effects of extradural bupivacaine in healthy dogs

Abstract

The aim of this research is to investigate the analgesic, haematologic and some
physiological effects of extradural bupivacaine on dogs using six clinically healthy
adult male dogs. The method used is by obtaining baseline data for physiological
variables from each dogs using the multiparameter patient monitors (GD3,
GenaralMeditech, Inc, China). Blood sample were also collected from the cephalic
vein after extradural administration of the drug. The onset of the analgesia was
determined using pin prick and the quality of analgesia with pre
scrotal urethrectomy. The physiologic variables, pulse and respiratory rate
including temperatures, blood pressure and oxygen saturation were recorded. Blood
samples for heamatology were collected at 30 minutes intervals after the drug
administration with the dog simultaneously undergoing pre scrotal urethrectomy for
bladder stones removal for one hour. The onset of the action was 29±11.34 and the
quality of analgesia was very good to excellent lasting for 128minutes. There was no
significant difference in values of all the physiologic parameters except the ECG
which showed significant level of arrthymia 30 minutes after the drug
administration. We therefore conclude that epidural bupivacaine produces very
good regional analgesic for pre scrotal urethrectomy and safe in Nigerian local
breeds of dogs.